Scientists have identified a potential connection between the onset of colon cancer and a ‘silent’ condition affecting over 80 million individuals in the United States. Colorectal cancer ranks as the second leading cause of cancer-related fatalities in the U.S., with 153,020 cases diagnosed in 2023 and more than 52,000 deaths, according to experts.
In recent years, there has been an alarming increase in colon cancer cases among younger populations, prompting research to understand the underlying reasons for this trend. One study has explored whether this rise in colon cancer among younger individuals may be linked to an often asymptomatic condition.
Non-alcoholic fatty liver disease (NAFLD) encompasses a range of conditions caused by the accumulation of fat in the liver. The NHS website notes that NAFLD typically occurs in individuals who are overweight or obese.
Although NAFLD usually does not inflict harm, it can cause significant liver damage if it advances to severe stages. Additionally, high levels of fat in the liver are linked with an elevated risk of serious health issues such as diabetes, high blood pressure, and kidney disease.
Researchers in South Korea discovered that individuals under 50 with a history of NAFLD were nearly 24 percent more likely to be diagnosed with colon cancer compared to those without the condition. Furthermore, those exhibiting early signs of NAFLD had a 12 percent higher risk of developing colon cancer than those without any history of the condition.
Though researchers emphasized the necessity for further studies to confirm these findings, they have gained a clearer understanding of how colon cancer might develop from this ‘silent’ condition. Essentially, inflammation resulting from NAFLD could extend to the colon, potentially damaging cellular DNA and leading to cancer cell formation.
The study, published in ScienceDirect, stated: “Our findings revealed a strong link between NAFLD and early-onset CRC in young adults, suggesting the importance of implementing effective preventive strategies, particularly in populations with a growing burden of metabolic dysfunction.”
“These findings highlight the need for multifaceted preventive strategies, including lifestyle interventions and expanded screening for younger populations with NAFLD.” Researchers are likely already conceptualizing future directions for this line of inquiry.