Bryan Johnson, the prominent biohacker known for trying to ‘live forever’, has shared findings suggesting magic mushrooms could negatively affect men.
Johnson is widely reported to spend around $2 million per year on efforts aimed at lowering his biological age, and he has taken part in a range of intense experiments as part of his push to slow — or even reverse — aging.
Now, the 48-year-old has outlined data examining how psilocybin, commonly referred to as magic mushrooms, may influence male reproductive health.
For the experiment, Johnson took two separate psilocybin doses: the first was 25 milligrams, followed by a second dose of 28 milligrams.
He focused specifically on sperm measurements. Prior to dosing, Johnson said his levels ranked in the 99.6th percentile compared with men under 25.
After the two doses, he documented a substantial shift. Sperm motility — the ability of sperm to swim effectively — fell by 51 percent.
By contrast, total sperm count showed only a small decline, dipping by about two percent, according to Johnson.
He also said many markers rebounded roughly 20 days after the second dose, although he reported sperm morphology was reduced by half.
Johnson added that sex hormone-binding globulin (SHBG) rose 37 percent following ingestion. SHBG plays a role in transporting sex hormones in the bloodstream and is involved in processes related to sperm production.
At the same time, elevated SHBG can be associated with problems such as reduced libido, fatigue, erectile dysfunction, and loss of muscle mass.
Johnson discussed some of the results earlier this month on Theo Von’s This Past Weekend podcast, saying: “Psilocybin sits in the world of psychedelics but it’s never been bridged to longevity, so we did an experiment. The data was surprisingly insane.”
Despite the apparent downsides for certain fertility-related metrics, Johnson suggested psilocybin produced other notable biological changes that he believes could be relevant to longevity research.
He said: “My blood glucose went from 98.2 percent in the population to 99.8 percent. It almost hit like a metabolic reset in the brain, resetting blood glucose regulation, which is gigantic.”
Johnson also claimed: “It took my inflammation levels down to undetectable, had changes in my microbiome, it legit is a longevity therapy,” he added.
It’s important to note that magic mushrooms are not recommended for everyone, and they may be particularly risky for people with certain mental health conditions, including schizophrenia and bipolar disorder.
If you want friendly, confidential advice about drugs, you can call American Addiction Centers on (313) 209-9137 24/7, or contact them through their website.