Prince Harry issued a response after an interviewer referenced the arrest of his uncle, Andrew Mountbatten-Windsor.
The Duke of Sussex, who previously stepped back from royal duties and relocated to the US with Meghan Markle, was in Jordan to back a number of humanitarian groups.
While there, he spoke with journalists and took questions, including from Channel 4 News senior political correspondent Paul McNamara.
Before the interview began, it appeared Harry had indicated he wanted the focus to remain on the humanitarian emergency in Gaza and the work he has been involved with alongside the World Health Organization.
However, the royal family has been facing intense scrutiny following the arrest of Andrew Mountbatten-Windsor on his birthday on suspicion of misconduct in public office.
At the outset of the February 27 interview, the subject was briefly acknowledged before moving on.
“I understand you don’t wish to talk about your family, your uncle, things back in London you’re here because you don’t want to distract from the work you’re doing on the WHO and on Gaza,” the Channel 4 correspondent told Harry.
He then immediately shifted to the purpose of the visit, asking: “Firstly, why are you here in Jordan? Why is it so important to you?”
The Duke of Sussex replied: “The work’s been going on for decades, but more so recently, it’s been a humanitarian hub for the Middle East, especially with everything that’s going on in Gaza, and also Syria, as well.”
He continued by warning that conflict in the region can be too easily ignored, saying “It was a really important time for us to collaborate and come here and shine a light and focus on the very real humanitarian catastrophe that has happened and continues.
Harry’s older brother, Prince William, also seemed to hint at heightened strain affecting the family in recent days.
While attending the BAFTAs on February 22, he was asked if he had seen Hamnet, and replied: “I need to be in quite a calm state and I am not at the moment.”
Andrew was arrested on suspicion of misconduct in public office after additional reporting about his links to convicted paedophile Jeffrey Epstein became public.
He spent several hours in police custody before being released while enquiries continue.
Andrew has denied any wrongdoing.
Following the arrest, King Charles issued a statement — reported as the first arrest of a senior royal since the reign of Charles I.
The statement said: “I have learned with the deepest concern the news about Andrew Mountbatten-Windsor and suspicion of misconduct in public office.
“What now follows is the full, fair and proper process by which this issue is investigated in the appropriate manner and by the appropriate authorities.”
The statement added: “In this, as I have said before, they have our full and wholehearted support and co-operation. Let me state clearly: the law must take its course. As this process continues, it would not be right for me to comment further on this matter.
“Meanwhile, my family and I will continue in our duty and service to you all. Charles R.”